Built on a direct farm-to-capsule supply chain in the Kashmir valley, Safralis is cold-milled whole stigma rather than an extract.

TEMPE, Ariz., Oct. 8, 2026 /PRNewswire/ — Nootropics Depot has launched Safralis, a high-potency Kashmir saffron made from whole stigma that is cold-milled rather than extracted, and standardized to 8% crocins and 3% safranals. Nootropics Depot uses exclusively Mongra-grade Kashmiri saffron, one of the region’s most prized grades. Its whole-stigma powder delivers exceptionally high concentrations of key bioactive compounds, ranking among the most potent saffron products on the market beating out all of the major commercially available extracts. The company is fully transitioning its saffron products to Safralis.

Safralis supports a positive mood, promotes cognitive function, and supports oxidative defenses and neuronal protection, functions backed by one of the deepest research bases of any botanical in its category. The mood evidence includes multiple randomized, placebo-controlled human trials plus systematic reviews and meta-analyses indicating that saffron supplementation supports mood and emotional wellbeing in healthy adults. The cognitive evidence spans human randomized trials, meta-analysis, and mechanistic work on crocin, crocetin, and safranal that research suggests supports cognitive function and attention. Crocin consistently supports oxidative defenses, including lipid peroxidation, DNA damage, and antioxidant enzymes, across cell, animal, and human research, including a placebo-controlled human trial. Each benefit is published on the Saffron Research Snapshot with its studies, part of Nootropics Depot’s research transparency pages.

The decision not to extract is what separates Safralis from the rest of the market. When you extract saffron you concentrate some compounds but lose others, and you can only extract what the plant makes naturally. Rather than build the most potent extract, Nootropics Depot went looking for the best raw material first. Saffron is prized for its color and aroma, and those qualities indicate the level of its bioactives, so the starting material determines the ceiling.

“You can only extract what the plant makes natively, so the smarter move is to find the best raw plant material first, via strain and region selection, then optimize its growing conditions to make the highest native amount of bioactives possible,” said Paul Eftang, CEO of Nootropics Depot. “We have made some of the most potent extracts in the world, and that experience is exactly why we chose the whole stigma here. Whenever you extract, you concentrate some compounds, but you always lose others. We wanted to keep the full spectrum of saffron bioactives intact, and if you can get extract level amounts of bioactives natively, why extract at all?”

To preserve that material, Safralis is cold-milled: the mill is chilled and the threads are ground with acacia fiber, which stabilizes the volatile safranal. Botanical identity is verified by HPTLC, and the product was developed in partnership with the scientists at Omnient Labs, who created more advanced methods for testing the bioactives in saffron. Safranal is measured together with its precursors picrocrocin and HTCC.

Securing whole Mongra stigma at this standard required control of the source. Kashmir produces less than 1% of the world saffron supply, and Mongra is a small fraction of that output. Nootropics Depot built a new direct farm-to-capsule supply chain in the Kashmir valley, working with longtime partners and relationships built over years. The global saffron trade has seen supply disruption and origin opacity, and direct sourcing gives Nootropics Depot full origin control and verification.

“It was no easy task to set up a reliable supply chain in Kashmir. The trust we built with the farmers there took a long time and a lot of work, and it is what made this product possible,” Eftang said. “An industry that wants consumer confidence has to control the whole process, from farm to capsule, and not just place its trust blindly in middle men.”

The no-extraction approach follows the method Nootropics Depot used for Erinamax, which produced the most potent erinacine A lion’s mane available by starting with superior raw material instead of concentrating it afterward. Nootropics Depot’s previous saffron extract was already the most potent on the market.

Safralis is offered in two strengths: 15 mg and 30 mg capsules. It can be taken once or twice a day. Both capsules deliver the same 8% crocins and 3% safranals. We decided to offer 15mg capsules, because the 30mg ones are a bit too strong for some people. It also allows for the ability to split the dose into morning and evening.

Safralis is the latest release in Nootropics Depot’s run of analytical and sourcing projects, following SulfoMax, the company’s highest-sulforaphane supplement at 27 mg of active sulforaphane per serving.

About Nootropics Depot

Nootropics Depot is a leading supplement company setting benchmark standards for quality and transparency in the industry. Founded in 2013, Nootropics Depot’s mission has been to educate consumers on the science behind dietary supplements, and to advance the lab testing and quality control standards of the industry. Their stance is that consumers should be able to trust the products they buy, and that the brands selling those products have a duty to ensure they are using modern validated science. Nootropics Depot offers a wide range of high-quality cognitive enhancement and general health supplements. The company’s commitment to quality and transparency is evident in their rigorous testing procedures, easily accessible Certificates of Analysis (COAs), and lab testing results available on every product page. In addition, they have formed a Scientific Advisory Board with board certified doctors, PhD researchers, and botanists to ensure that consumers can trust that scientific rigor is being upheld in everything they do. For more information, visit nootropicsdepot.com.

Media Contact:
Michael Packman, Nootropics Depot
michael@nootropicsdepot.com

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